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脱羟基在有机反应中的应用

脱羟基在有机反应中的应用

最近遇到不少求助和询问关于脱羟基反应,在这里我给大家总结一下脱羟基反应类型,希望对大家有用.脱羟基反应继Zn-Hg浓盐酸还原和黄明龙还原羰基到亚甲基的另一种合成亚甲基的方法,在有机合成中有着重要的作用,就羟基的还原的反应方法,本人总结如下,纯属个人愚见,欢迎大家积极讨论和补充.
1. Et3SiH/TFA or Ph3SiH/TFA

2. Pd/C, H2

3. LiAlH4, AlCl3 

4. NaBH4/TFA;
Sodium borohydride in trifluoroacetic acid reduces diarylmethanols and triarylmethols; to the corresponding diarylmethanes and triaryl methanes in excellent yield.

5. HI
Some hydoxyl  group has been replaced by hydrogen by refluxing with  HI acid  

6. SmI2
Synthesis of alkyl pyridine derivatives by SmI2 mediated deoxygenation of pyridinemethanol derivatives

7. TMSCl/NaI
TMSI in MeCN selectively reduces moderately electron deficient to the analogous toluenes; other reduction sensitive functional groups such as ketones, aldehyde, nitrile, and nitro are unaffected. 

8. Other methods

9. the conversion of hydroxyl for hydrogenation

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