曼尼希反应

这种不可烯醇化的醛，伯胺或仲胺和可烯醇化的羰基化合物的这种多组分缩合产生氨基甲基化产物。醛的亚胺衍生物是反应中的受体。

已经在许多生物合成途径中提出了曼尼希反应的参与，特别是对于生物碱。

曼尼希反应的机制

Recent Literature  近期文献

An Efficient, Mild, Solvent-Free, One-Pot Three-Component Mannich Reaction Catalyzed by (C₄H₁₂N₂)₂[BiCl₆]Cl·H₂O
H. Lu, R. Wu, H. Cheng, S. Nie, Y. Tang, Y. Gao, Z. Luo, Synthesis, 2015, 47, 1280-1290.

Transition Metal Salt-Catalyzed Direct Three-Component Mannich Reactions of Aldehydes, Ketones, and Carbamates: Efficient Synthesis of N-Protected β-Aryl-β-Amino Ketone Compounds
L.-W. Xu, C.-G. Xia, L. Li, J. Org. Chem., 2004, 69, 8482-8484.

Catalytic Silicon-Mediated Carbon-Carbon Bond-Forming Reactions of Unactivated Amides
S. Kobayashi, H. Kiyohara, M. Yamaguchi, J. Am. Chem. Soc., 2011, 133, 708-711.