Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones

• Timothy E. Hurst

• Julie A. Deichert

• Lucas Kapeniak

• Roland Lee

• Jesse Harris

• Philip G. Jessop*

• Victor Snieckus*

Cite This:Org. Lett.2019XXXXXXXXXX-XXX

Publication Date:May 24, 2019

https://doi.org/10.1021/acs.orglett.9b00773

Abstract

Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting the differential reactivity of sodium methyl carbonate with Grignard and organolithium reagents.