此反应Michael加成引发的关环反应，可以通过此反应制备三元、五元、六元和七元环。此反应最常用的底物是砜类化合物，[3+2]环加成最容易进行。

反应操作

Trans, trans trisubstituted methylenecyclopentane (3). To a stirred solution of 1 (1 equiv) in THF was added LDA (1.3 equiv) in THF at -78 ℃. After 15 min, 2 (1.1 equiv) was added, the mixture was stirred for 45 min. Quenching (aq HCl), extraction (Et2O-20% DCM) and chromatography afforded 3 in 75% yield.

【Hassner A, Ghera E, Tet Lett., 1990, 31, 3653】

相关文献

1 Ghera E Tet Lett 1979 4603

2 Little RD Tet Lett 1980 21 2609

3 Hassner A, Ghera E Tet Lett 1990 31 3653

4 Hassner A, Ghera E J Org Chem 1996 61 4959

5* Hassner A Tet Asymm 1996 7 2423

6* Hassner A Tet Asymm 1998 9 2201

7* Hassner A Tet Lett 2000 41 5583, 8157

8 Hassner A Pure Appl Chem 2000 72 1671

9* Hassner A Eur J Org Chem 2001 1259

10 Hassner A Tet Asymm 2001 12 2269

11 Tanino K Eur J Org Chem 2006 328

12 Dumez E Chem Eur J 2009 15 12470

编译自：Organic Syntheses Based On Name Reactions, 3RdEd, A. Hassner, Page 205.