3-羰基戊二酸酯和邻二羰基化合物在缓冲溶液中缩合得到顺式-双环[3.3.0]辛烷-3,7-二酮（cis-bicyclo[3.3.0]octane-3,7-dione）的反应。产物极易脱羧。

反应机理

一分子的3-羰基戊二酸酯先和邻二羰基化合物缩合生成环戊二烯酮，接着与另一分子的3-羰基戊二酸酯经过两次迈克尔加成得到产物。

反应实例

参考文献

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11. Galatsis, P. Weiss–Cook Reaction, In Name Reactions for Carbocyclic Ring Formations, Li, J. J., Ed.; Wiley: Hoboken, NJ, 2010, pp 181–196. (Review).

编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Weiss–Cook condensation，page 624-625.