苯胺和β-酮酯在酸催化下或受热后给出4-喹啉酮。参见Combes反应。

反应机理

反应实例

参考文献

1. Conrad, M.; Limpach, L. Ber. 1887, 20,944.

2. Manske, R. F. Chem Rev.1942, 30, 113–114. (Review).

3. Misani, F.; Bogert, M. T. J.Org. Chem. 1945, 10, 347–365

4. Reitsema, R. H. Chem. Rev.1948, 43, 43–68. (Review).

5. Elderfield, R. C. In Chemistryof Heterocyclic Compounds, Elderfield, R. C., Wiley & Sons, New York, 1952, vol.4, 31–36. (Review).

6. Jones, G. In HeterocyclicCompounds, Jones, G., ed.; Wiley & Sons, New York, 1977, Quinolines, Vol 32, 137–151.(Review).

7. Deady, L. W.; Werden, D. M. Synth.Commun. 1987, 17, 319-328.

8. Kemp, D. S.; Bowen, B. R. TetrahedronLett. 1988, 29, 5077-5080.

9. Curran, T. T. Conrad–LimpachReaction. In Name Reactions in Heterocyclic Chemistry; Li, J. J., Ed.; Wiley: Hoboken,NJ, 2005, pp 398-406. (Review).

10. Chan, B. K.; Ciufolini, M.A. J. Org. Chem. 2008, 72, 8489-8495.

11. Lengyel, L.; Nagy, T. Z.;Sipos, G.; Jones, R.; Dormán, G.; Üerge, L.; Darvas, F. Tetrahedron Lett. 2012, 53,738-743.

摘自：有机人名反应——机理及应用 第四版